For an oocyte to become All set for fertilization and development into an embryo, the proper set of genes has to be turned on. Namekawa suspected that this pre-programming of your oocyte genome comes about in quite a few stages — the main one starting round the time a female is born. He thought that chromatin remodeling proteins did Significantly of this perform, by shifting spools about.
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Utilizing the GCRLE grant, Munakata and Namekawa will look much more intently at how oocytes are genomically primed and saved for afterwards use. They can investigate the role of the chromatin remodeler in oocyte survival and fertility.
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Munakata and Namekawa will Assess mice with standard and mutated versions from the chromatin remodeler. As the mice improve and experienced, they can notice whether the existence or absence of the protein triggers variances in the arrangement of DNA spools within the animals’ oocytes. And they will check whether this, subsequently, alters the pattern of gene expression eventually.
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